Several research teams of the Allen School focus on antimicrobial resistance and the emerging issues that come from the spread of resistant zoonotic diseases. Work spans the genetic study of resistant E coli to wider epidemiological studies of resistant food-borne pathogens and to the development of alternatives to antibiotic treatments for disease.
The following snippets offer a short overview into the research projects of the school. Click on a link to the researcher profiles for more detailed information about their work. If you are interested in learning more about Allen School antimicrobial resistance initiatives, visit that page when you’re done here.
Escherichia coli and Salmonella enterica
Researcher: Dr. Douglas Call
Dr. Call’s team examines the mechanisms that lead to the emergence, amplification, persistence, and dissemination of antibiotic resistance in food animal production systems. Following that work, they have gone on to develop vaccine, microcin, and probiotic tools to combat zoonotic pathogens independent of antibiotics. Some of this research depends on the development of algorithms to rapidly genotype and fingerprint bacteria using next-generation sequencing.
Alternatives to Antibiotics
Researcher: Dr. Tom Kawula
Dr. Kawula’s group is developing small molecule treatments that control specific bacterial infections via mechanism that are fundamentally different from traditional antimicrobial (antibiotic) agents. These alternative treatments work by enhancing or complementing natural host immune mechanism, or by altering host processes that inadvertently support pathogen replication and survival.
Determinants of Antibiotic Resistance
Researcher: Dr. Margaret Davis
Dr. Davis’ lab explores the causes of antimicrobial resistance in bacterial pathogens. Through a focus on the molecular epidemiology of zoonotic food-borne pathogens, her team has examined multi-drug antimicrobial resistance in Salmonella enterica and other Gram-negative bacteria.
Infectious Disease Surveillance
Researcher: Dr. Timothy Baszler
Dr. Baszler’s research projects study the advancement and delivery of tools for laboratory diagnosticians and regulatory disease officials. This work focuses on global infectious disease surveillance and diagnostic capacity building in developing countries. His team recognizes that effective animal health services are essential in the development of systems that can detect emerging resistant pathogens as well as endemic pathogens of importance to both human and animal health.
Shao Lu is a graduate student in the IID program. Finishing in 2018, he has been researching regulation, inhibition, and self-immunity of a small antimicrobial peptide known as microcin PDI. When reflecting on his WSU experience, Shao said, “My first time visiting WSU, I noticed quickly the diversity of the graduate student body - people from various parts of the world with different cultures and scientific expertise working together. In addition, a diverse and dedicated group of faculty and staff in the program are passionate about mentoring and supporting the students to ensure their success."