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NEWSLETTER | JULY/AUGUST 2014
Graduate student Jessica Klein in the lab of Dr. Leigh Knodler
Allen School for Global Animal Health faculty members and affiliates are well-represented among recent awardees of the College of Veterinary Medicine’s Intramural Research Grants. Funded projects range from a population-level study of the prevalence and health consequences of a diarrheal disease pathogen in Nairobi, Kenya, to laboratory-based work to better understand the action of a specific protein found within the zoonotic Brucella bacteria. These projects represent the Allen School’s focus on research into the basic processes of infectious disease, leading to new approaches to prevent and control disease transmission in both animals and humans. Funded Intramural Grant projects include:Dr. Jennifer Zambriski: “Frequency and prevalence of Cryptosporidium spp and association with growth deficits in children living in an urban slum in Nairobi, Kenya”;
Dr. Viveka Vadyvaloo: “Verifying small non-coding RNA production in Yersinia pestis flea adaptation”;
Dr. Anders Omsland: “Significance of gluconeogenic capacity for Coxiella burnetii replication”;
Dr. Felix Lankester: “Canine rabies vaccine: A thermostability trial”;
Dr. Leigh Knodler: “Role of the type III translocon in vacuole lysis”;
Dr. Jean Celli: “Mode of action of the Brucella effector protein BspB”;
Dr. Doug Call: “Turning the tables on antimicrobial resistance”;
Dr. Kelly Brayton: “The Role of OMP7-10 in Protective Immunity”;
Dr. Hector Aguilar-Carreño: “Unraveling the role of cellular factors in viral entry and cell-cell fusion.”
With the support of CVM grants of about $20,000 each, the Allen School researchers can advance their work and also use findings as preliminary data for larger funding proposals.
Dr. Anders Omsland was awarded a WSU New Faculty Seed Grant of $30,000 for his project “Establishment of a genetic system to study the gene dksA in Chlamydia.”
Dr. Solomon Ramabu, adjunct faculty member based at the Botswana College of Agriculture, University of Botswana, has received $66,000 for a three-year project titled “Anaplasma marginale infection among cattle in the South East District of Botswana: Prevalence and molecular characterization.” The research is funded by the Botswana College of Agriculture.
Addwebi, T, DR Call, and D Shah. 2014. Contribution of Salmonella Enteritidis virulence factors to the intestinal colonization and systemic dissemination in day-old chickens. Poultry Science 93(4):871-81. doi: 10.3382/ps.2013-03710.
Davenport, EK, DR Call, and H Beyenal. 2014. Differential protection from tobramycin by extracellular polymeric substances from Acinetobacter baumannii and Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy 03071-14. [Epub ahead of print].
Eberhart, LJ, JN Ochoa, TE Besser, and DR Call. 2014. Microcin MccPDI reduces the prevalence of susceptible Escherichia coli in neonatal calves. Journal of Applied Microbiology doi: 10.1111/jam.12535.
Hammac, GK, S Aguilar Pierlé, X Cheng, GA Scoles, and KA Brayton. Global transcriptional analysis reveals surface remodeling of Anaplasma marginale in the tick vector. Parasites and Vectors. PMCID: PMC4022386. 7: 193. 2014.
LaFrentz, BR, SE LaPatra, DR Call and KD Cain. 2014. Immunization of rainbow trout Oncorhynchus mykiss (Walbaum) with a crude lipopolysaccharide extract of Flavobacterium psychrophilum. Aquaculture Research 45:476-483.
Long, A, DR Call, and KD Cain. 2014. Investigation of the link between broodstock infection, vertical transmission, and prevalence of Flavobacterium psychrophilum, in eggs and progeny of rainbow trout and Coho salmon. Journal of Aquatic Animal Health 26(2):66-77. doi: 10.1080/08997659.2014.886632.
Miller, CB, S Aguilar Pierlé, KA Brayton, JN Ochoa, DH Shah, and KK Lahmers. Transcriptional Profiling of a Cross-Protective Salmonella enterica serovar Typhimurium UK-1 dam Mutant Identifies a Set of Genes More Transcriptionally Active Compared to Wild-Type, and Stably Transcribed across Biologically Relevant Microenvironments. Pathogens. 3: 417-436. 2014.
Pratap N, MA Memon, O Mahgoub, Y Al-Shikaili, RS Al-Habsi, BE Hago. Breeding soundness examination, semen freezing and evaluation of frozen-thawed semen in native Omani bulls – Preliminary study. Clinical Theriogenology 6: 85-92, 2014.
Student and Fellow News
Sara Ahmed, student of Dr. Margaret Davis, successfully defended her MS thesis entitled “Evidence for dissemination of clonally related Esherichia coli Strains Carrying Extended-Spectrumβ-Lactamase CTX-M in Washington State Dairy Farms.”
Moses Ole-Neselle, student of Dr. Tom Marsh, successfully defended his MS thesis. His project was titled “Does Foot and Mouth disease zoning impact African meat exports?”
Cameron Mandel, a first year DVM student, was awarded a CVM Summer Research Fellowship for a project titled “Nutrient deprivation and metabolic consequences in growth of Coxiella burnetii,” in the lab of Dr. Anders Omsland.
Quan Liu, PhD student in the lab of Dr. Hector Aguilar-Carreno, was awarded a one-year, $24,780 Poncin Scholarship for her project titled “Uncovering a region in the Nipah virus attachment protein stalk important for triggering membrane fusion.”
Jackie Stone, PhD student in the lab of Dr. Hector Aguilar-Carreno, was awarded a one-year, $24,780 Poncin Scholarship for her project “Investigating Nipah virus entry into host cells.”
Darin Weed, PhD student in the lab of Dr. Anthony Nicola, has been granted an NSF Graduate Research Fellowship Program award, for his project on the molecular mechanism of herpes simplex virus membrane fusion.
Sebastián Aguilar Pierlé, in the lab of Dr. Kelly Brayton, was awarded a highly competitive 2-year Cantarini post-doctoral fellowship to work at the Institut Pasteur with Didier Mazel. He will be working on Characterization of Vibrio cholerae genes involved in SOS and oxidative stress responses and their impact on persister formation.
Paul Ervin, a School of Economic Sciences graduate student studying with Dr. Jon Yoder, was awarded a $15,000 grant with the United Nations Development Programme as "Specialist in Health, Poverty, and Inequality" to explore the economics of dengue and traffic accidents in Paraguay.
Paul Ervin, mentored by Dr. Yoder, presented "Rabies post-exposure treatment demand and the value of a statistical life in Tanzania" at the Midwest Economics Association conference, Evanston, IL, in March.
Craigen Nes and his WSU Global Case Competition teammates were recently awarded a full travel award to travel to Bangladesh for 7-10 days this fall. The award is a result of the team’s first place finish in the WSU competition on the theme of “Preventing Arsenic Poisoning in Bangladesh,” held this past spring. The travel award will enable them to work locally on their approach to addressing the arsenic problem. Craigen is a PhD student in the lab of Dr. Viveka Vadyvaloo.
Cory Gall, PhD student of Dr. Kelly Brayton, received a travel award to attend the 8th annual Arthropod Genomics Symposium June 12-14, 2014, in Champaign, Illinois. He presented a talk entitled “Characterization and disruption of Dermacentor andersoni bacterial microbiome.”
Undergraduate students Floricel Gonzales, a microbiology and English major mentored by Dr. Anthony Nicola, and Samantha McInally, a microbiology major mentored by Dr. Hector Aguilar-Carreno, were awarded 2014-2015 Auvil Fellowships of $1,000 each to conduct their research. The students will present their work at WSU’s 2015 Showcase for Undergraduate Research and Creative Activities (SURCA) event.
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Faculty and Staff News
Dr. Michelle (Shelley) McGuire, Associate Professor in the School of Biological Sciences, is a new affiliate faculty member in the Allen School. Shelley's expertise is related to human nutrition during the lifecycle, especially during lactation and infancy. Along with Dr. Courtney Meehan (Department of Anthropology), Shelley is currently overseeing an NSF-funded grant involving several other faculty members at WSU, University of Idaho, and other national and international locations (e.g., Kenya, Ethiopia, The Gambia, Ghana), aimed at understanding environmental and genetic factors related to variation in the human milk microbiome and infant's gastrointestinal microbiome. Janae Mosely and Kimberly Lackey, graduate students in the McGuire laboratory, presented posters related to the human microbiome at the Experimental Biology meetings held in San Diego in April, and Janae received the top prize for a poster she presented at the University of Idaho's Inland Northwest Genomics Research Symposium in June. Shelley traveled to Dhaka, Bangladesh in July to deliver the keynote talk related to maternal nutrition and pregnancy outcome at a medical conference attended by local physicians. Dr. McGuire is excited to collaborate with others in the Allen School also interested in global nutrition. Please contact her if you would like to talk about overlapping research interests.
Dr. Mohammad Obaidat is currently visiting Dr. Margaret Davis’s lab to learn techniques for genotyping bacterial pathogens. Genotyping bacteria can be useful to investigate the epidemiology of foodborne pathogens such as Salmonella and E. coli from farm to table. Dr. Obaidat earned his Master’s from Kansas State University and his PhD from the University of Georgia in Food Safety, specializing in foodborne pathogens. He is also Diplomate of the American College of Veterinary Preventive Medicine. Currently, Dr. Obaidat is Professor of Food Safety and Zoonotic Diseases at Jordan University of Science and Technology and is conducting field studies in Jordan to assess antimicrobial resistance in dairy cattle and small ruminants in Jordan.
Dr. Sibusiso Mtshali arrived June 10 for a 3-month sabbatical to work/train on Anaplasma marginale genomics in the lab of Dr. Kelly Brayton. Dr. Mtshali is a Senior Researcher at the National Zoological Gardens of South Africa.
Dr. Jane Lwoyero arrived May 4th from Nairobi, Kenya, and completed her Norman Borlaug Fellowship in Dr. Call’s lab on July 16th. Dr. Lwoyero worked on a project to determine if antibiotic residues in poultry products can enrich populations of resistant bacteria under storage conditions typical of informal markets in Nairobi. She learned a suite of new skills that she will employ in a newly established food safety lab with the Directorate of Veterinary Services in Kenya.
The recently published 3rd edition of Skills for Communicating with Patients (Radcliffe Publishing: London and New York), co-authored by Dr. Suzanne Kurtz has been 'Highly Commended' in the Basis of Medicine category of the 2014 British Medical Association's Medical Book Awards.
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Dr. Jennifer Zambriski presented an invited lecture in Peru this past June at the NIH Fogarty International Center’s meeting Bridging the Andes: Enhancing Public Health Research in Peru and Bolivia.
Drs. Dale Moore, Bill Sischo and Suzanne Kurtz presented a workshop on “Assessing and Improving Dairy Business Communication” at the Academy of Dairy Veterinarians conference, Seattle, WA, April 26, 2014. The workshop disseminated and applied findings from the USDA-funded project "Minimizing antibiotic resistance transmission: The dairy farm as a model system", Dr. Margaret Davis, PI.
Dr. Suzanne Kurtz co-facilitated a workshop on “How best to develop the IRCCH's training and professional development agenda” at the 3rd Roundtable of the International Research Centre for Communication in Healthcare (IRCCH), Lugano, Switzerland, June 25, 2014.
Dr. Kurtz also served on a panel entitled Articulated Values and Skilled Communication - The Foundation of Humanistic Care, at the Communication, Medicine, and Ethics (COMET) annual conference, Lugano, Switzerland, June 27, 2014. Dr. Kurtz presented on “Human dimensions of care: Communication strategies for enhancing their effectiveness in healthcare interactions.”
Dr. Douglas Call and members of his lab presented findings the American Society for Microbiology General Meeting, 17-20 May 2014, Boston, MA. Poster presentations included:
- Lone, A, L Orfe, H Beyenal, E Atci, JJ Park, DR Gang, B Fransson, S Nohy, N Abu-Lail, and DR Call. Porcine explant model yields multiple soluble compounds of physiological importance from MRSA biofilms.
- Eberhart, LJ, Z Zhao, SY Lu, L Orfe, TE Besser, and DR Call. OmpF is necessary for microcin MccPDI activity against susceptible E. coli.
- Liu, J, S Lu, Z Zhao, M Subbiah, D Mobley, L Orfe, S Nydam, J Ullman, L Matthews, and DR Call. Excreted ceftiofur and florfenicol from cattle amplify resistant E. coli populations in soil.
- Subbiah, M, L Orfe, O Strom, G de la Cruz, G Cilingir, SL Broschat, I O Olatoye, and DR Call. Application of high-resolution melt analysis to track the molecular epidemiology of tetracycline resistance from E. coli and Salmonella.
Other items of interest:
Recent article by Dr. Alan Kelly et al. in The Lancet Global Health: Veterinary medicine’s increasing role in global heath
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