Allen School faculty are involved as co-investigators on two additional Gates Foundation Grand Challenge Explorations awards led by researchers at the University of Washington and the Institute for Health Metrics and Evaluation.
Dr. Peter Rabinowitz of the University of Washington will lead a Grand Challenges Explorations project titled One House-One Health Approach to Child Growth and Development: Identifying and Resetting High Risk Household Gut Microbiomes. Recent studies have highlighted the importance of the gut microbiome in childhood nutritional status, growth and development. Together with colleagues at WSU and the Center for Disease Control and Prevention, Kenya, Dr. Rabinowitz will test whether unhealthy gut microbes in livestock that reside closely with humans in smallholder households can negatively influence the gut microbes in the humans. They will analyze the gut microbiomes of healthy and unhealthy children and co-residing companion and domestic animals in selected households in western Kenya to determine whether they are related. If they are, they will reset the animal microbiomes using established fecal transplant methods and determine whether there is a corresponding positive effect on the microbiomes of the rest of the household. Allen School faculty members Doug Call, Tom Marsh, Terry McElwain, Samuel Thumbi Mwangi, Guy Palmer, Jon Yoder and Jennifer Zambriski are co-investigators.
Dr. Ali Mokdad of the Institute for Health Metrics and Evaluation is the Principal Investigator on One Metric for One Health: A New Approach to Measure and Evaluate the Nexus of Animal and Human Health. Dr. Mokdad will lead a team of researchers to integrate data on animal health and its determinants to better understand and monitor human health and opportunity in the developing world. Data from Zambia on environmental factors such as temperature and rainfall will be integrated with data on the condition and sales of animals and crops as well as human disease burden and mortality to create a unified measure of the impact of animal health and productivity and environmental/climate factors on human health and well-being. The team will also make recommendations for improved data collection. Allen School faculty members Tom Marsh and Guy Palmer are co-investigators.
These three awards address “The ‘One Health’ Concept: Bringing Together Human and Animal Health for New Solutions” topic area. Successful projects have the opportunity to receive future support up to $1 million. For a complete list of Round 11 Grand Challenge Explorations awards see:http://www.grandchallenges.org/Explorations/Pages/GrantsAwarded.aspx