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NEWSLETTER | JAN / FEB 2014
1) UFV’s Luis A Nero, President Nilda Soares and Eduardo Mizubuti; (2) WSU’s Allen School Director Guy Palmer; (3) Luis Nero; UW’s Peter Rabinowitz, Christina Pettan-Brewer, Michael Morgan and King Holmes; (4) Christina Pettan-Brewer, King Holmes and Judy Wasserheit (UW); (5) (back) Wes Van Voorhis (UW); WSU’s Guy Palmer, Doug Call, Jean Celli and Leigh Knodler; Eduardo Mizubuti; (front) Hector Aguilar-Carreno (WSU); King Holmes, Christina Pettan-Brewer, and Nilda Soares; Jenni Zambriski (WSU).
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One World, One Health
The Paul G. Allen School for Global Animal Health is working in partnership with the University of Washington and Universidade Federal de Viçosa (UFV), Brazil, to develop collaborative ONE HEALTH research and training programs. Last fall, the Allen School hosted a day-long symposium to discuss these partners’ joint interests including zoonotic and emerging/neglected infectious diseases, antimicrobial resistance, and drug and vaccine development for protozoal diseases. Faculty members from the three institutions shared presentations on their research programs, and followed up with discussions of opportunities for integration of interdisciplinary, ONE HEALTH research focused on Brazil. The day also featured a tour of WSU’s Washington Animal Disease Diagnostic Laboratory (WADDL) and Veterinary Teaching Hospital. Dr. Christina Pettan-Brewer of the UW School of Medicine spearheaded the effort, building on her experience in infectious disease research and developing international exchange programs between veterinarians and veterinary medicine students in the US and her native Brazil. “This is a great opportunity for us to extend our global health partnership with UW into longstanding collaborations among WSU and Brazilian colleagues” summarized Dr. Guy Palmer, Director of the Allen School. Read More
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Research News Grand Challenge Explorations Grant Recipient
Allen School Assistant Research Professor Dr. Thumbi Mwangi is the recipient of a recent Grand Challenge Explorations grant from the Bill and Melinda Gates Foundation. His project, titled Integrated Control of Syndemic Diseases: Malaria, East Coast Fever, and Worms, will test whether treatment of parasitic helminth infections reduces the severity of co-occurring parasitic diseases malaria and East Coast Fever (ECF), leading causes of morbidity and mortality in humans and cattle, respectively, in sub-Saharan Africa. This work will be conducted in Kenya in collaboration with the Kenya Medical Research Institute. Read More
Allen School faculty are involved as co-investigators on two additional Gates Foundation Grand Challenge Explorations awards led by researchers at the University of Washington and the Institute for Health Metrics and Evaluation. Read More
NIH MERIT Award
A grant renewal titled "Antigenic variation in microbial transmission" has been awarded to Drs. Guy Palmer (PI) and Kelly Brayton. The project examines the role of population immunity in driving genomic change in microbial pathogens.
Congratulations to faculty on the following new publications:
Hammac, G.K., Ku, P.-S., Galletti, M.F., Noh, S.M., Scoles, G.A., Palmer, G.H., and Brayton, K.A. (2013) Protective immunity induced by immunization with a live, cultured Anaplasma marginale strain. Vaccine, 35:3617-3622.
Knodler, L.A., Nair, V. and Steele-Mortimer, O. (2014) Quantitative assessment of cytosolic Salmonella in epithelial cells. PLoS One, in press.
Laughlin, R.C., Knodler, L.A., Barhoumi, R., Payne, H.R., Wu, J., Gomez, G., Pugh, R., Lawhon, S.D., Bäumler, A.J., Steele-Mortimer, O. and Adams, L.G. (2014) Spatial segregation of virulence gene expression during acute enteric infection with Salmonella enterica serovar Typhimurium”. mBio, in press.
Long, A., Fehringer, T.R., Swain, M.A., LaFrentz, B.R., Call, D.R., and Cain, K.D. (2103) Enhanced efficacy of an attenuated Flavobacterium psychrophilum strain cultured under iron-limited conditions. Fish and Shellfish Immunology 35:1477-1482.
Palmer, G.H. and Brayton, K.A. (2013) Antigenic variation and transmission fitness as drivers of bacterial strain structure. Cellular Microbiology, 15:1969-1975.
Zhou, Y., Call, D.R., and Broschat, S. (2013) Whole-proteome and 16S rRNA analyses of pathogenic strains of Alphaproteobacteria. Pathogens 2:627-635.
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2014 Seminar Series
Advances in Infectious Diseases &
Sponsored by the NIH T32 Post-doctoral Training Program in Infectious Diseases and Microbial Immunology, the Department of Veterinary Microbiology and Pathology, the School of Molecular Biosciences & the Paul G. Allen School for Global Animal Health
All talks at 12:10 pm in ADBF Room 1002
Kim Orth, PhD, W.W. Caruth, Jr. Scholar in Biomedical Research; Earl A. Forsythe Chair in Biomedical Science at UT Southwestern.
Topic: Type III effectors in bacterial pathogenesis
Host: Kelly Brayton
Jason Carlyon, PhD, Associate Professor of Microbiology and Immunology and Blick Scholar in Infectious Diseases, Virginia Commonwealth University School of Medicine
Topic: Rickettsial pathogenesis
Host: Susan Noh
Michael Gale, Jr., PhD, Professor of Immunology, Department of Immunology, University of Washington School of Medicine
Topic: Innate immunity in infectious disease
Host: Guy Palmer
Dan Haydon, PhD, Director of Institute/Professor of Population Ecology and Epidemiology, Institute of Biodiversity, Animal Health and Comparative Medicine), University of Glasgow
Topic: Infectious diseases epidemiology and modeling
Host: Doug Call
Sandy Weller, PhD, Distinguished Professor and Chair, Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Sciences Center
Topic: Herpesviral pathogenesis
Host: Anthony Nicola
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Student and Fellow News
Marie Wrande, post-doctoral associate in the lab of Dr. Leigh Knodler, was awarded a four year grant from The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), to study Salmonella derived factors affecting its survival in the cytosol of intestinal epithelial cells, and activation of caspase-4 inflammasome by enteric bacteria. The award supports Dr. Wrande for 16 months training at the Allen School from her home university of Karolinska Institute, Stockholm, Sweden.
Neeraj Suthar, student of Dr. Margaret Davis, completed his Master’s degree in the Immunology and Infectious Disease Graduate Program. Neeraj’s project was titled “An individual-based model of transmission of resistant bacteria in a veterinary teaching hospital.”
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Faculty and Staff News
Dr. Guy Palmer was recently re-appointed to the Board on Global Health at the Institute of Medicine through 2016. Dr. Palmer has also been re-appointed to the Editorial Board of Infection and Immunity through 2016, and is newly appointed to the International Scientific Advisory Board for the Nelson Mandela African institute of Science and Technology, Tanzania, 2013-2016.
Dr. Felix Lankester, based in Arusha, TZ, was appointed an External Supervisor for post-graduate and Master's students at Nelson Mandela African Institute for Science and Technology.
Drs. Hector Aguilar-Carreno and Doug Call were elected to 3-year terms on the WSU College of Veterinary Medicine’s Immunology and Infectious Disease graduate program Executive Committee. Dr. Mushtaq Memon was elected to serve on Board of Directors of the Fulbright Association, the official alumni organization of the Fulbright Scholarship program.
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Dr. Felix Lankester presented “Malignant catarrhal fever: a vaccine trial and an economic impact assessment” at the Tanzanian Wildlife Research Institute’s 9th International Scientific Conference, December 4-6, 2013.
Dr. Leigh Knodler was an invited speaker at the 4th American Society for Microbiology (ASM) conference on Salmonella, October 5-9, Boston. Her talk was titled "Epithelial cell sensing of cytosolic Salmonella."
Drs. Knodler and Jean Celli were invited speakers at the ASM Northwest Branch meeting, November 16, Seattle. Dr. Knodler presented "Cytosolic Salmonella: when, how and why?" and Dr. Celli on "Brucella modulation of the host secretory pathway via VirB Type IV secretion effector proteins."
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