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NEWSLETTER | NOV/DEC 2015
 
 

 

Allen School Faculty Mentor Student Researchers, Award Winners

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Allen School graduate students and post-doctoral associates, as well as DVM students engaged in summer research projects with Allen School faculty members, were among presenters and top award winners at the 17th Annual College of Veterinary Medicine Student Research Symposium this October.

Tying for first place in the Resident, Post-doctoral and Graduate Student category were Cheryl Miller, post-doc in the lab of Dr. Jean Celli, and Jessica Klein, PhD student in the lab of Dr. Leigh Knodler. Dr. Miller’s poster was titled “The Brucella Type IV effector BspB targets the Golgi apparatus to inhibit host secretory trafficking,” and Ms. Klein presented her poster “Functional complementation of Inv/Mxi-Spa Type III secretion system translocator operon in Salmonella enterica.”

Taking 1st place in the DVM Student, Undergraduate, and Intern Projects category was Marley Iredale, DVM ’17, mentored by Dr. Gretchen Kaufman, with her poster “Determining the Cause of Ulcerative Shell Disease in the Western Pond Turtle.”

In total, 19 posters were presented by students mentored by Allen School faculty members or affiliates, including five by CVM Summer Research Grant awardees:

Joni Anderson: “Using phenotype microarray technology to analyze metabolic changes induced in murine macrophages infected by Coxiella burnetii.” Mentor: Dr. Anders Omsland.

Kelsey Brown: “Role of animal products containing antibiotic residues on antibiotic-resistant enteric bacteria of consumers in Kenya.” Mentor: Dr. Douglas Call.

Lance Kidder: “Effects of age and previous exposure on calf resistance to reinfection with Cryptosporidium parvum.” Mentor: Dr. Jennifer Zambriski.

Katharine Reardon: “Assessing the potential of Nipah virus-like particles as future vaccines.” Mentor: Dr. Hector Aguilar-Carreño.

Carson Sakamoto: “Molecular characterization and antimicrobial resistance of Salmonella Kentucky isolates from humans and poultry.” Mentor: Dr. Devendra Shah.

Please see Student and Fellow News, below, for a list of other presentations by Allen School students and affiliates.

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marley-iredale
From top: Dr. Cheryl Miller, Ms. Jessica Klein, and Ms. Marley Iredale are presented 1st place awards by Dr. Robert Mealey, CVM Associate Dean for Research
 

WSU and Allen School Host University of Nairobi Officials

WSU and Allen School Host University of Nairobi Officials

Dr. Terry McElwain, right, gives a tour of the WSU Veterinary Teaching Hospital to University of Nairobi visitors, from left, Vice Chancellor Peter Mbithi, Dr. James Machoki, Deputy Director of the Institute of Tropical and Infectious Disease, and Dr. Isaac Ongubo, Principal, College of Health Sciences.

Officials from the University of Nairobi, Kenya, visited the WSU Pullman campus October 14-15 for meetings with faculty and administrators to discuss opportunities for collaboration. In addition to meeting with Drs. Guy Palmer and Terry McElwain of the Allen School, UoN Vice Chancellor Peter Mbithi and colleagues met with WSU Interim President Dr. Dan Bernardo, Dean of the Graduate School Dr. William Andrefsky, Acting Dean of CAHNRS Dr. Kim Kidwell, Vice President for Research Dr. Chris Keane, Vice President for International Programs Dr. Asif Chaudhry, and Associate Vice President for Research, Operations and Support Dan Nordquist. The visitors learned about WSU’s role as a public land-grant research university and development of partnerships for PhD programs and international research grants.

Notes from the Field:

Global Pathway student Cassie Eakins

Global Pathway student Cassie Eakins arrived in Tanzania on 26th October to spend five weeks working with the Serengeti Health Initiative field team led by Dr. Felix Lankester, collecting data for her project assessing the parasite burden of community dogs in rural villages of northern Tanzania.

Cassie reports: The work here is going really well! I'm learning a lot about overcoming the challenges of working in the field with limited resources, especially how to accept that things don't always work out the way you planned. However, despite the difficulties I'm absolutely loving Tanzania and the people I am able to meet every day here. This country is stunningly beautiful and I'm so grateful for the opportunity to work here!

 

 

Research News

 
 

Grants Awarded:

Dr. M.K. Njenga

Dr. M.K. Njenga

Dr. M.K. Njenga is PI on a new Centers for Disease Control and Prevention award, “Preventing zoonotic diseases (GHSA #3) in Kenya” ($2,500,000; 09/30/15 – 09/29/20). Working with key collaborators in Kenya, the goal of the project is to improve the country’s ability to control zoonotic diseases by enhancing its ability to respond to zoonotic disease outbreaks, establishing near real-time zoonotic disease surveillance in animals (including wildlife), and strengthening the animal disease workforce. Co-investigators are Drs. Terry McElwain and S. Thumbi Mwangi.

Dr. Massaro Ueti is PI on a new grant funded by the USDA AFRI Foundational Animal Health & Disease Program, titled "A pioneering approach to tick control: Anti-tick toxins delivered via a tick transmissible pathogen." Co-investigators are Drs. Glen Scoles, Carlos Suarez, Kelly Brayton and Audrey Lau.

Dr. Douglas Call is a co-investigator on a USDA AFRI award, “Flavobacterial diversity and its effect on disease in aquaculture” (subcontract to Dr. Call $78,563; 11/01/15 – 10/31/18.) PI: Dr. Thomas Loch, Michigan State University.

Dr. Michelle (Shelley) McGuire is a co-investigator on a NSF BEACON subaward titled, “Has evolution of human milk sugars responded to a biocultural sweet tooth?” ($124,500; 05/01/15 – 04/30/17.)

Dr. Jennifer Zambriski has been awarded a one year, $284,286 supplement to her Bill & Melinda Gates Foundation award, "Pharmacokinetics, efficacy, and synergism of nitazoxanide and azithromycin in the treatment of cryptosporidiosis." This research aims to inform dosing protocols for future clinical trials to be conducted by the Foundation in human pediatric populations in resource-poor countries.

 

Congratulations to faculty, staff and students on recent publications:

Carrothers JM, York MA, Brooker SL, Lackey KA, Williams JE, Shafii B, Price WJ, Settles M, McGuire MA, McGuire MK. (2015). Fecal microbial community structure is stable over time and related to variation in macronutrient and micronutrient intakes in lactating women. The Journal of Nutrition 145(10):2379-2388. doi: 10.3945/jn.115.211110

Kelly KM, Wack AN, Bradway D, Simons BW, Bronson E, Osterhout G, Parrish NM, Montali RJ. (2015). Identification of Mycobacterium genavense in a Diana Monkey (Cercopithecus diana) by polymerase chain reaction and high-performance liquid chromotaography. Journal of Zoo and Wildlife Medicine 46(2):339-344. doi: 10.1638/2013-0246R2.1

LeCuyer TE, Rink A, Bradway DS, Evermann JF, Nicola AV, Baszler T, Haldorson GJ. (2015). Abortion in a Mediterranean miniature donkey (Equus asinus) associated with a gammaherpesvirus similar to Equid herpesvirus- 7. Journal of Veterinary Diagnostic Investigation 27(6):749-753. doi: 10.1177/1040638715611444

McGuire S. (2015). Reports from the Agencies: FAO, IFAD and WFP. 2015. The state of food insecurity in the world 2015. Meeting the 2015 international hunger targets: taking stock of uneven progress. Advances in Nutrition 6(5):623-624. doi: 10.3945/an.115.009936

McGuire S. (2015). Reports from the Agencies: Institute of Medicine and National Research Council. Examining a developmental approach to childhood obesity: The fetal and early childhood years: workshop in brief. Advances in Nutrition 6(4):487-488. doi: 10.3945/an.115.009381

McGuire S. (2015). Reports from the Agencies: International Food Policy Research Institute. 2014. Global Nutrition Report 2014: Actions and accountability to accelerate the world’s progress on nutrition. Advances in Nutrition 6(3):278-279. doi: 10.3945/an.115.008599

McGuire S. (2015). Reports from the Agencies: Expenditures on Children by Families, 2013. Washington DC: US Department of Agriculture, Center for Nutrition Policy and Promotion; 2014. Miscellaneous Publication No. 1528-2013. Advances in Nutrition 6(2):227-228. doi: 10.3945/an.115.008227

McGuire S. (2015). Reports from the Agencies: World Health Organization. Comprehensive Implementation Plan on Maternal, Infant, and Young Child Nutrition. Geneva, Switzerland, 2014. Advances in Nutrition 6(1):134-135. doi: 10.3945/an.114.007781

Minyoo AB, Steinmetz M, Czupryna A, Bigambo M, Mzimbiri I, Powell G, Gwakisa P, Lankester F. (2015). Incentives increase participation in mass dog rabies vaccination clinics and methods of coverage estimation are assessed to be accurate. PLoS Neglected Tropical Diseases 9(12):e0004221. doi: 10.1371/journal.pntd.0004221

Suedmeyer WK, Stockinger B, Garner MM, Bradway DS, Holliner C, and Kiupel M. (2015). T-Cell lymphocytic leukemia in a fallow deer (Dama dama). Journal of Zoo and Wildlife Medicine 46(3):580-582. doi: 10.1638/2014-0207.1.

Sultana ST, Atci E, Babauta JT, Falghoush AM, Snekvik KR, Call DR, Beyenal H. (2015). Electrochemical scaffold generates localized, low concentration of hydrogen peroxide that inhibits bacterial pathogens and biofilms. Scientific Reports 5:14908. doi: 10.1038/srep14908

Walker E, Pritchard S, Cunha CW, Aguilar HC, Nicola AV. (2015). Polyethylene glycol-mediated fusion of herpes simplex type I virions with the plasma membrane of cells that support endocytic entry. Virology Journal 12: 190. doi: 101186/s12985-015-0423-0

Yahvah KM, Brooker SL, Williams JE, Settles M, McGuire MA, McGuire MK. (2015). Elevated dairy fat intake by lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or sythesis. Nutrition Research 35(3):221-228. doi: 10.1016/j.nutres.2015.01.004

Zhao Y, Yang C, Organ C, Li Z, Bhushan S, Otsuka H, Pacheco A, Kang J, Aguilar HC, Lefer DJ, Xian M. (2015). Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors. Journal of Medicinal Chemistry, 58(18):7501-7511. doi: 10.1021/acs.jmedchem.5b01033

Zhao Z, Eberhart LJ, Orfe LH, Lu SY, Besser TE, Call DR. (2015). Genome-wide screening identifies six genes that are associated with susceptibility to Escherichia coli microcin PDI. Applied and Environmental Microbiology 81(20):6953-6963. doi: 10.1128/AEM.01704-15

Student and Fellow News

Dr. Jackie Stone

Dr. Jackie Stone

Jacquelyn Stone, student of Dr. Hector Aguilar-Carreño, successfully defended her doctoral thesis, titled “The role of the Nipah Virus G head and stalk regions in modulating viral fusion.” Committee members also included Dr. Anthony Nicola, Dr. Mary Sanchez Lanier, and Dr. Leigh Knodler.

Cory Gall, PhD student of Dr. Kelly Brayton, was awarded the 2015 Fowler Emerging Diseases Graduate Fellowship. The Fowler Emerging Diseases Graduate Fellowship was established in 2013 as a gift from Ron Fowler in memory of his father, Ralph Fowler.

Jessica Klein, student of Dr. Leigh Knodler, gave a seminar at the American Society of Microbiology Northwest meeting in Seattle November 21-22. The title of her talk was “Functional complementation of the Inv/Mxi-Spa type III secretion system translocator operon in Salmonella enterica."

Three undergraduate Animal Science majors working on research in the lab of Dr. Jennifer Zambriski have been admitted to WSU’s competitive 7-year DVM program. The three students, Natalie Hurst, Anna Aversa, and Janey Beumeler, all sophomores, will matriculate into this prestigious program after completion of their junior year.

Posters presented at the 17th Annual College of Veterinary Medicine Student Research Symposium:

Kim Lam Chiok: “Overexpression of catalytically inactive KsgA in Salmonella Enteritidis affects cellular morphology and impairs intra-cellular survival in epithelial and phagocytic cells.” Advisor: Dr. Devendra Shah

Jacob Elder: “Contribution of Salmonella Pathogenicity Island 13 to the pathogenicity and metabolic fitness of Salmonella Enteritidis.” Advisor: Dr. Devendra Shah

Jinxin Liu: “Soil-borne reservoirs of antibiotic resistant bacteria are established following therapeutic treatment of dairy calves.” Advisor: Dr. Douglas Call

Shao Lu: “Osmoregulation is key to E. coli microcin MccPDI production and inhibition.” Advisor: Dr. Douglas Call

Paul Narayan: “Assessment of antimicrobial activity of chlorine against most prevalent poultry Salmonella serotypes in a chicken-meat-based model.” Advisor: Dr. Devendra Shah

Tri Komala Sari: “The role of Herpes Simplex Virus Type 1 (HSV-1) gC in pathway-specific entry into host cells.” Advisor: Dr. Anthony Nicola

Erin Smith: “Modulation of the host secretory pathway by the Brucella effector BspF.” Advisor: Dr. Jean Celli

Michael Snyder: “Identifying source and dissemination pathways of antimicrobial resistance on dairies.” Advisor: Dr. Bill Sischo

Jackie Stone: “Novel flow cytometry method reveals a bi-dentate interaction between paramyxovirus attachment & fusion proteins.” Advisor: Dr. Hector Aguilar-Carreño

Darin Weed: “Reversibility of low pH-induced conformational changes in HSV gB.” Advisor: Dr. Anthony Nicola

George Wudiri: “Influence of the hydrocarbon tail of sterols in the HSV-1 envelope on viral entry and infectivity.” Advisor: Dr. Anthony Nicola

Faculty and Staff News

Dr. Tom Marsh

Dr. Tom Marsh

Dr. Tom Marsh was named a Fellow of the American Association for the Advancement of Science, honored for his contributions to agricultural economics, particularly the use of novel econometric approaches to define risks of invasive species and transboundary livestock diseases.

Dr. Marsh was an invited participant at the Tanzania Livestock Modernisation Initiative, Dar es Salaam, summer 2015. This was a multidisciplinary symposia of government officials, university and industry experts worldwide, organized to address the state of livestock development in Tanzania. A report resulting from the forum was presented to the President of Tanzania.

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Dr. Hector Aguilar-Carreño receiving his award from Dr. Robert Mealey

Dr. Hector Aguilar-Carreño was presented the College of Veterinary Medicine Dean’s Award for Outstanding Research, October, 2015.

 

This fall was a busy time for faculty presentations nationally and internationally:

Two faculty members delivered invited presentations at the Mexican Biochemical Society’s Bacterial Biochemistry and Molecular Biology meeting in Atlixco/Metepec, Puebla, Mexico, October 4-8, 2015. Dr. Jean Celli presented the keynote address, titled "Intracellular pathogenesis of Brucella abortus: it's all about secretion." Dr. Leigh Knodler presented an invited seminar titled “New insights into the intracellular pathogenesis of Salmonella.”

The International Symposia of Veterinary Epidemiology and Economics was held in Merida, Yucatan, Mexico, November 3-7, 2015, with the following presentations by Allen School faculty members:

Dr. Jonathan Yoder presented a talk, “The economic impact of malignant catarrhal fever on pastoralist livelihoods.” Authors: Felix Lankester, Ahmed Lugelo, Rudovick Kazwala, Julius Keyyu, Sarah Cleaveland, Jonathan Yoder.

Dr. Tom Marsh presented two talks: “Trade impacts of pests and pathogens: The case of Foot and Mouth Disease,” co-author Umesh Bastola, and “Household behavior and livestock diseases: The case of Foot-and-Mouth Disease in Tanzania,” co-authors Umesh Bastola, Tiziana Lembo, Sarah Cleaveland, Miriam Casey, Harriet Auty, Tito Kibona and Deogratius Mshanga.

Christine Crudo, Dr. Bill Sischo and Dr. Doug Call co-authored a poster titled, “Mathematical modeling of infectious disease: The interaction of science and social science in disease response,” presented by Ms. Crudo.

American Society of Microbiology - Northwest branch held its meeting in Seattle, November 21-22, 2015, with the following presentations by Allen School faculty members:

Dr. Viveka Vadyvaloo presented a talk titled, “Investigating free-living amoeba as an enzootic host for the bubonic plague.”

Dr. Anders Omsland presented a talk, “Metabolic adaptations to obligate intracellular parasitism.”

Dr. Jean Celli presented a talk, "Modulation of host secretory trafficking by the Brucella effector BspB."

Dr. Douglas Call was an invited speaker at the XXVIII Brazilian Congress of Microbiology, held in Florianoplois – SC, Brazil, October 18-22, 2015. The title of his talk was “Controlling antibiotic resistance in food animal production.”

Dr. Call also presented an invited lecture, “Antimicrobial resistance: Moving beyond the prudent use paradigm” at Oregon State University, Eugene, Oregon, October 6, 2015, and was an invited facilitator for a “Community Conversation” on antibiotic resistance, sponsored by the Northwest Association for Biomedical Research, September 28, 2015, Spokane, WA.

Dr. Tom Marsh delivered an invited talk titled, “Economics of zoonotic diseases: The case of avian influenza,” at the American Veterinary Medical Association Economic Summit, October 21, 2015, in Rosemont, IL. He also presented an invited seminar, “Household food expenditures, macronutrients, and One Health: Evidence from smallholders in Kenya,” Oklahoma State University, November 2015.

Gates Grand Challenges

Invited guests at the Gates Grand Challenges meeting in Beijing included, from left, Drs. Jeff Mariner, Jennifer Zambriski, Paul Wood, Nick Juleff, and Marshall Lightowlers

Dr. Jennifer Zambriski was invited to attend the Bill & Melinda Gates Foundation Grand Challenges meeting in Beijing, China, October 19-21, to discuss future chemotherapeutics, diagnostics, and research priorities for Cryptosporidium. Other attendees included world leaders in global animal health presenting research on topics including plans for eradication of Pestis de Petit Ruminants, novel methods of Foot and Mouth Disease surveillance, and new approaches to anthelmintic resistance.

 

Dr. Dan Bradway gave the following presentations at the 58th Annual American Association of Veterinary Laboratory Diagnosticians meeting in Providence, RI, October 2015:

  • “Pseudocowpox viral epidermitis in a mountain goat: another zoonotic Parapox virus causing contagious ecthyma in wild ruminants.” Authors: Nelson DD, Munoz J, Bradway DS, and Wolff PL.
  • “Elimination of a centrifugation step in the NAHLN avian influenza RNA extraction protocol does not impact assay sensitivity.” Authors: Crossley B, Breitmeyer R, Bradway D, Baszler T, McElwain TF, Mulrooney D, Heidel J, Tomlinson S, Loiacano C, Pedersen J, Torchetti M, and Reising M.
  • Bluetongue Virus in the Pacific Northwest: a diagnostic perspective.” Nelson DD, Wolff PL, Mansfield KG, Johnson DJ, Bradway DS, Evermann JF, and Baszler TV.
  • “Clinicopathological findings and virus antigen distribution during natural infection of ring-necked pheasants in Washington State, USA with highly pathogenic avian influenza virus A (H5N2).” Authors: Ajithdoss DK, Torchetti MK, Badcoe L, Bradway DS, and Baszler TV.
 
 
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